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KMID : 0370019940080000125
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Chung-Ang Journal of Pharmacal Sciences
1994 Volume.8 No. 0 p.125 ~ p.132
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The Effect of Diphenyl-dimethyl-dicarboxylate and the Derivatives on Complete Freund´s Adjuvant induced Inflammation in Rats
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Abstract
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PMC(Dimethyl-4,4´-dimethoxy-5,6-5´,6´-dimethylene dioxybiphenyl-2,2´-dicarboxlylate) and its derivatives, PMC1(4,4´-Dimethoxy-5,6-5´,6´-dimethylene dioxybiphenyl-2,2´-dicarboxylic acid) and PMC2(Dimethyl-4,4´-dihydroxy-5,6-5´,6´-dimethylene dioxybiphenyl-2,3´-dicaboxylate), were administered orally to mice and rats in order to investigate the anti-inflammatory effects.
The results are as follows;
1. the anti-inflammatory effects of PMC, PMC1 and PMC2 were significant on hind paw carrageenin induced edema in rats.
2. PMC, PMC1 and PMC2 inhibited dose-dependently the capillary permeability of pontamin sky blue in mice administered HAc intraperitoneally
3. PMC, PMC1 and PMC2 had significant anti-inflammatory effects on hind paw edema induced by complete Freund´s adjuvant in rats.
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